What are the classifications of pharmaceutical intermediates?

March 18, 2020. From January to December 2005, the total output value of China's chemical raw material pharmaceutical industry reached 116.277 billion yuan, a year-on-year increase of 33.51%; The profit was 6.78 billion yuan, a year-on-year increase of 27.5%; Especially the export volume reached 7.903 billion US dollars, an increase of 27.55% compared to the same period last year. From these economic indicators, the pharmaceutical industry still maintains a significant growth trend. Pharmaceutical intermediate manufacturers believe that the prospects of the pharmaceutical market are promising and will inevitably drive the strength of upstream pharmaceutical intermediates.
Traditionally, the intermediates required for drug production were mostly produced by pharmaceutical companies themselves. But in recent years, with the deepening of social division of labor and the progress of production technology, some pharmaceutical intermediate production has gradually separated from the production of pharmaceutical enterprises and transferred to the production of chemical enterprises. From an international perspective, pharmaceutical intermediates have become a major industry in the international chemical industry.
What are common pharmaceutical intermediates? Pharmaceutical intermediates refer to chemical raw materials or products used in the pharmaceutical synthesis process. From the development history of China's pharmaceutical intermediate industry, after nearly 30 years of development, pharmaceutical intermediates have developed from a small branch of the chemical industry to an emerging industry with a value of billions of yuan, and their market competition has become increasingly fierce. Below, the editor will introduce several common pharmaceutical intermediates to you:
N-benzyl-N-methylethanolamine
N-benzyl-N-methylethanolamine is an important pharmaceutical intermediate that can synthesize anti asthma and anti allergic drugs, as well as the antihypertensive drug nicardipine and some new cardiovascular disease drugs; In addition, pesticides, herbicides, plant fungicides, and metal preservatives can also be synthesized.
4,4 '- Dimethoxyacetoacetate methyl ester
4,4 '- Dimethoxyacetoacetate methyl ester is an important intermediate of nifedipine for the treatment of cardiovascular and cerebrovascular diseases. It is currently the leading treatment drug for cardiovascular and cerebrovascular diseases in the international market and has not been produced domestically. Methyl di methoxyacetic acid was synthesized from glyoxylic acid and trimethyl orthoformate in the presence of concentrated sulfuric acid. The latter reacted with methyl acetate and sodium methoxide to obtain methyl 4,4 '- dimethoxyacetoacetate.
α- Methylene cyclohexanone
α- Methylene cyclohexanone is an active center of many anticancer drugs, which contains α,β- Unsaturated ketone structures belong to the hidden functional groups of anticancer active groups and become important intermediates for the synthesis of many important cyclic anticancer drugs. 
4-Propylthio-phenylenediamine
4-Propylthio-phenylenediamine is a key intermediate of the efficient broad-spectrum insecticidal drug albendazole. albendazole is a new drug that was only launched in the late 1980s and has low toxicity to humans and animals. It is a strong traditional Chinese medicine of benzimidazole drugs.