Are customized pharmaceutical intermediates toxic?

Firstly, we need to understand which link you belong to in the pharmaceutical intermediate customization industry. Generally, some related trading companies or sales departments do not have direct contact with those products, so there is no safety issue. If it is a frontline factory, it depends on what the factory produces and what process is used, such as producing butyl acetate as an intermediate for penicillin. If esterification is used, acetic acid and butyl acetate are added to the reactor for esterification. The harm to the human body is relatively small, but the harm to the human body is greater using a one-step synthesis method. Due to different varieties of products, sodium sulfite produced by some companies can only be supplied to aliphatic raw materials, which is basically harmless.
Now let's give an example, which is a dye intermediate that poses significant harm to the environment and the body.
Production process of dye intermediates
The production of dye intermediates involves the following processes: sulfonation, nitration, reduction, halogenation, amination, oxidation, acylation, alkylation, and other chemical reactions of basic organic raw materials such as benzene, naphthalene, and anthracene, resulting in the formation of organic compounds with more complex structures than the original ones but without dye characteristics, such as H acid, earth acid, J acid, etc.
Dye intermediates are produced into raw dyes through reaction processes such as diazotization and coupling.
The raw dye is then treated with dyes to produce commercial dyes.
The production process of dyes consumes a large amount of raw materials, with a material consumption of several tons to tens of tons per ton. At the same time, during its production process, it often requires one or more water washes, resulting in a large amount of by-products or waste, especially a large amount of waste liquid.