A brief introduction to chemical and pharmaceutical intermediates!

Chemical and pharmaceutical intermediates refer to semi-finished products, which are intermediate products in the production of certain products. For example, to produce a product, it can be produced from intermediates to save costs. Intermediates are formed by reactions such as sulfonation, alkali melting, nitration, and reduction of cyclic compounds such as benzene, naphthalene, and anthracene. For example, benzene is nitrated to nitrobenzene, which is then reduced to aniline. Aniline can be chemically processed into dyes, drugs, vulcanization accelerators, etc. Nitrobenzene and aniline are both intermediates. It is also formed from acyclic compounds such as methane, acetylene, propylene, butane, butene, etc. through dehydrogenation, polymerization, halogenation, hydrolysis, and other reactions. For example, butane or butene can be dehydrogenated into butadiene, which can be chemically processed into synthetic rubber, synthetic fibers, etc. Butadiene is an intermediate. Z initially refers to the intermediate products produced in the process of synthesizing spices, dyes, resins, drugs, plasticizers, rubber accelerators and other chemical products with coal tar or petroleum products as raw materials. It now refers to various intermediate products obtained in the process of organic synthesis. concept The so-called pharmaceutical intermediates are actually some chemical raw materials or products used in the process of drug synthesis. This chemical product does not require a drug production license and can be produced in ordinary chemical factories. As long as it reaches certain levels, it can be used for the synthesis of drugs. effect Drug production requires a large number of special chemicals, which were originally mostly produced by the pharmaceutical industry itself. However, with the deepening of social division of labor and the advancement of production technology, the pharmaceutical industry has transferred some pharmaceutical intermediates to chemical enterprises for production. Pharmaceutical intermediates are fine chemical products, and the production of pharmaceutical intermediates has become a major industry in the international chemical industry. In cell biology, intermediates refer to the central part of the gradually disintegrating spindle around the equatorial surface at the late stage of cell division, where the concentration of cytoplasm around increases and fills the whole equatorial surface. This thickening area is called intermediates.

2022/08/07

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Customization and application of pharmaceutical intermediates

China is a major producer and supplier of customized pharmaceutical intermediates, with broad development prospects. Among them, 1,2,4-trichlorobenzene, o-cresol, catechol, and nonylphenol are important pesticide intermediates. 1,2,4-trichlorobenzene is mainly used in the synthesis of pesticides such as dichlorvos, acaricide sulfone, sodium pentachlorophenol, and pentachlorophenol; O-cresol is mainly used for the synthesis of efficient herbicides; Catechol is an intermediate of carbofuran, propoxur and ethmocarb, which are important new carbamate pesticides with low toxicity and high efficiency; Nonylphenol is a versatile non ionic surfactant widely used as a pesticide emulsifier; M-cresol is mainly used to synthesize pesticides and insecticides. In recent years, due to the gradual strengthening of the development and application of downstream products at home and abroad, there is a strong demand for high-purity 1,2,4-trichlorobenzene in the international market. In addition, due to the prohibition and restriction of the use of lindane, traditional raw materials for trichlorobenzene are increasingly decreasing in developed countries and regions abroad, and the production of organic chlorine products is also gradually decreasing. This has also led to a shortage of global supply of trichlorobenzene, especially high-purity 1,2,4-trichlorobenzene. These factors provide great opportunities for the production and development of 1,2,4-trichlorobenzene in China. New carbamate insecticides produced by catechol, such as carbofuran, propoxur and ethmocarb, are recommended by the World Health Organization as excellent varieties of household pest and storage pest control agents due to their low toxicity and good effects. The market demand will also gradually increase. Nonylphenol is a bulk product of Z in Alkylphenol, which has good functions of decontamination, wetting, penetration, dispersion, solubilization and emulsification. It is widely used as pesticide emulsifier, and is an important intermediate of Z in petrochemical industry and organic synthesis industry. The market demand for m-cresol has maintained a stable growth rate at an average annual rate of 8% to 10%. In addition, due to the advantages of functionalization, high-performance, specialized flowers, and high added value, fine chemical engineering is a low-carbon, environmentally friendly process that is essential for achieving the national energy-saving and emission reduction goals and developing a low-carbon economy. The country has greatly increased its attention to it. It is also very beneficial for the development of the fine chemical pesticide intermediate industry. Therefore, the fine chemical pesticide pharmaceutical intermediate industry in China has a very good development prospect under the dual favorable influence of increasing market demand and government encouragement for development.

2022/08/01

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Introduction to Pharmaceutical Intermediates

April 1, 2020. Chemical and pharmaceutical intermediates are actually some chemical raw materials or products used in the process of drug synthesis. When used in the synthesis of some drugs, the term 'pharmaceutical intermediate' should be considered as a general term for some chemical products, such as o-nitrobenzaldehyde. It is used for the anti heart pain drug nitropyridine (heartache drug) and reduces the nitro group to an amino group to form o-aminobenzaldehyde, which can be used to synthesize quinoline ring drugs. This product is mainly used as a pharmaceutical and dye intermediate, as well as a reagent for detecting acetone. The domestic pharmaceutical intermediate industry has entered a mature stage, and the early days when a few skilled workers could make profits have passed. There will also be no situation where a basic intermediate such as aminothiazide can supply more than a dozen drugs for production. With the development of the pharmaceutical industry, new demands for pharmaceutical intermediates will continue to emerge, such as aztreonam intermediates. However, these new products have not yet formed a significant market demand. Currently, the pharmaceutical intermediates with a relatively high demand in China are mainly traditional series products such as aminothiazide acid, demethylaminothiazide acid, and their derivatives. New projects should be carefully considered by enterprises, and the timing of intervention should be reasonably grasped on the premise of having sufficient funds and technical strength, as well as maintaining good relationships with pharmaceutical companies; In addition, we have a good understanding of the dynamics of our domestic and international peers, as well as upstream and downstream trends, and are proactive in seizing market opportunities.

2022/07/12

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What are chemical and pharmaceutical intermediates?

On October 30, 2020, chemical pharmaceutical intermediates are a fine chemical product used in the production process from pharmaceutical raw materials to raw materials or drugs. The synthesis of chemical drugs relies on high-quality pharmaceutical intermediates. This chemical product does not require a drug production license and can be produced in ordinary chemical factories. As long as it reaches certain levels, it can be used for the synthesis of drugs. China requires more than 2000 types of raw materials and intermediates that are matched with chemical industry every year, with a demand of over 2.5 million tons. After years of development, the chemical raw materials and intermediates required for pharmaceutical production in China can basically be matched. There are many types of pharmaceutical intermediates, which can be divided into antibiotic drug intermediates, antipyretic and analgesic drug intermediates, cardiovascular system drug intermediates, and anticancer drug intermediates according to their application fields. There are many specific types of pharmaceutical intermediate products, such as imidazole, furan, phenolic intermediate, aromatic intermediate, pyrrole, pyridine, biochemical reagent, sulfur containing, nitrogen containing, halogen compound, heterocyclic compound, starch, mannitol, microcrystalline cellulose, lactose, dextrin, ethylene glycol, sugar powder, inorganic salt, ethanol intermediate, stearate, amino acid, ethanolamine, potassium salt, etc Sodium salts and other intermediates, etc. In addition, in recent years, due to increasingly strict drug regulatory requirements, increasing difficulty in drug research and development, and rising prices, multinational pharmaceutical companies have gradually shifted from a "vertical integration" business model to a "development cooperation" business model in order to shorten the time to market of patented drugs, reduce research and production costs, maintain good profit margins throughout the entire drug lifecycle, and improve their own business efficiency Professional decomposition of business processes such as development and production, and outsourcing to professional institutions such as pharmaceutical contract research enterprises and pharmaceutical customization research and development production enterprises.

2022/06/21

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