Customization and application of pharmaceutical intermediates

China is a major producer and supplier of customized pharmaceutical intermediates, with broad development prospects. Among them, 1,2,4-trichlorobenzene, o-cresol, catechol, and nonylphenol are important pesticide intermediates. 1,2,4-trichlorobenzene is mainly used in the synthesis of pesticides such as dichlorvos, acaricide sulfone, sodium pentachlorophenol, and pentachlorophenol; O-cresol is mainly used for the synthesis of efficient herbicides; Catechol is an intermediate of carbofuran, propoxur and ethmocarb, which are important new carbamate pesticides with low toxicity and high efficiency; Nonylphenol is a versatile non ionic surfactant widely used as a pesticide emulsifier; M-cresol is mainly used to synthesize pesticides and insecticides.
In recent years, due to the gradual strengthening of the development and application of downstream products at home and abroad, there is a strong demand for high-purity 1,2,4-trichlorobenzene in the international market. In addition, due to the prohibition and restriction of the use of lindane, traditional raw materials for trichlorobenzene are increasingly decreasing in developed countries and regions abroad, and the production of organic chlorine products is also gradually decreasing. This has also led to a shortage of global supply of trichlorobenzene, especially high-purity 1,2,4-trichlorobenzene. These factors provide great opportunities for the production and development of 1,2,4-trichlorobenzene in China.
New carbamate insecticides produced by catechol, such as carbofuran, propoxur and ethmocarb, are recommended by the World Health Organization as excellent varieties of household pest and storage pest control agents due to their low toxicity and good effects. The market demand will also gradually increase.
Nonylphenol is a bulk product of Z in Alkylphenol, which has good functions of decontamination, wetting, penetration, dispersion, solubilization and emulsification. It is widely used as pesticide emulsifier, and is an important intermediate of Z in petrochemical industry and organic synthesis industry. The market demand for m-cresol has maintained a stable growth rate at an average annual rate of 8% to 10%.
In addition, due to the advantages of functionalization, high-performance, specialized flowers, and high added value, fine chemical engineering is a low-carbon, environmentally friendly process that is essential for achieving the national energy-saving and emission reduction goals and developing a low-carbon economy. The country has greatly increased its attention to it. It is also very beneficial for the development of the fine chemical pesticide intermediate industry.
Therefore, the fine chemical pesticide pharmaceutical intermediate industry in China has a very good development prospect under the dual favorable influence of increasing market demand and government encouragement for development.