Characteristics of Chemical and Pharmaceutical Intermediates

At present, the quinolone antibiotics that have been developed and put into mass production by chemical pharmaceutical intermediates in China mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, fleroxacin, etc. Among them, the production of norfloxacin, ciprofloxacin, and ofloxacin is Z, accounting for approximately 98% of the total production of fluoroquinolone antibiotics in China.
Quinolones are generally synthesized from fluorinated benzene rings and then condensed with piperazine (or methylpiperazine). Due to the abundant reserves of fluorite in China, it is one of the countries with the largest production of fluorinated drugs and intermediates in the world, with over 80% of fluorinated intermediates supplied for export. Overall, the development of fluorobenzene intermediates in China is relatively early, and the current production capacity is generally surplus; The development of trifluoromethylene intermediates was relatively late and has been growing rapidly in recent years; For heterocyclic aromatic compounds, especially fluorinated pyridines, only a few research units and manufacturers in China currently have the synthesis technology of fluorinated pyridine intermediates. Therefore, fluorinated pyridine intermediates will become one of the main directions for the research and development of fluorinated intermediates in China in the coming years. China has become the world's largest producer of antipyretic and analgesic drugs, with production of over 10000 tons of aspirin, paracetamol, and analgin, as well as over 1000 tons of phenacetin, aminopyrine, and antipyrine. At present, the production of antipyretic and analgesic drugs in China is growing rapidly, and it is expected to continue to grow at a rate of around 8% in the future. The production of intermediates for antipyretic and analgesic drugs is large, and there are many production enterprises. With the growth of antipyretic and analgesic drugs, intermediates have also made significant progress.
In 2003, the consumption of paracetamol in China rapidly increased, and exports also showed a rapid growth trend. The export volume was 28163 tons, with a year-on-year increase of about twice the annual export volume. Although its export growth rate slowed down in the first half of 2004, it still showed some growth. From January to May 2004, the export volume of paracetamol was 12501 tons, slightly higher than the same period last year. Paraaminophenol is an important intermediate in the synthesis of paracetamol and has also grown rapidly in recent years. At present, the annual production of paracetamol in China is about 32000 tons. It is expected that by 2005, the domestic production of paracetamol will reach over 50000 tons, and the pharmaceutical industry will consume 45000 tons of paracetamol. In addition, the total demand for paracetamol in 2005 was about 50000 tons, with a large market gap and broad prospects for development and utilization.